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How to Use Argireline Serum: The Correct Way for Best Results
Argireline only works if applied properly — and most people unknowingly use it wrong. Here is the correct, dermatologist-approved method.
12/12/20251 min read
Step-by-Step Routine
Cleanse (AM + PM)
Apply Argireline FIRST — directly on expression lines
Layer Hyaluronic Acid
Apply moisturiser
Apply SPF (AM mandatory)
Why Argireline Must Be Applied First
It needs direct contact with the skin’s neurotransmitter receptors.
If you put other serums first, you block absorption.
How Much to Use
1–2 drops per area (forehead, eyes, 11s).
How Long to Use It For
Forever.
Anti-ageing ingredients work cumulatively — stopping means slowly going backwards.
Best Ingredients to Combine With Argireline
Hyaluronic Acid
Niacinamide
Glycerin
Copper peptides
Ceramides
Betaine
Worst Mistakes
✖ Applying after moisturiser
✖ Using once a day
✖ Using only for a few weeks
✖ Not using SPF
Conclusion
Use Argireline consistently — morning and night — and it will visibly relax expression lines and smooth skin.