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How to Layer Argireline Correctly (Avoid These Mistakes!)
Argireline is powerful — but only if you use it correctly. Many people layer it wrong and never see full results. Here’s the correct, dermatologist-approved guide.
12/12/20251 min read
Step 1: Cleanser
Start with a gentle, non-stripping cleanser.
No exfoliating acids. No foaming sulphates.
Step 2: Apply Argireline FIRST
This is where most people go wrong.
Argireline must be applied:
✔ On clean skin
✔ Before other serums
✔ Before moisturiser
Why?
Because it’s a small peptide that needs to reach the nerve-communicating pathways (neuromuscular junction).
Step 3: Apply Your Other Serums
These layer well:
Hyaluronic acid
Niacinamide
Peptides
Ceramides
Vitamin B5
Avoid layering AHAs at the same time — acids can reduce peptide effectiveness.
Step 4: Moisturiser
Lock everything in with a lightweight moisturiser.
Step 5 (AM only): Sunscreen
Essential. UV exposure accelerates expression lines.
Common Mistakes to Avoid
❌ Mixing with strong acids
❌ Applying after thick serums
❌ Only using it once a day (twice is better)
❌ Using too little product
❌ Only applying it where lines already exist
Summary
Layering Argireline correctly can double its effectiveness.
Apply it first, use it consistently, and keep your barrier healthy — and your wrinkles will soften noticeably.